If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Elimination of Interferences in Spectral Data

$29.00 plus tax (Refund Policy)

Buy Article:

Abstract:

A general-purpose method for eliminating one or more interferences from spectra in a completely objective way is described. The method, called least-squares subtraction, depends only on the linearity of the spectra and the linear independence of the analyte's spectrum from those of the interferences. The spectrum that results after correction is modified from the spectrum of the pure analyte, but it can still be used for quantitation and identification. Because of this modification, the method is best applied to problems where the presence of the analyte is obscured by the interferences, or when fast, automatic removal of one or more time-varying interferences from a series of spectra is required. The method is illustrated by the removal of a strong interference from the ATR measurement of the infrared spectrum of an enzyme-substrate complex and the removal of a changing chromatographic baseline from the output of a liquid chromatograph's diode array detector.

Keywords: Automatic correction; Baseline correction; Computer algorithm; Spectral subtraction

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702894203499

Affiliations: Hewlett-Packard Laboratories, P.O. Box 10490, Palo Alto, California 94303-0971

Publication date: September 1, 1989

More about this publication?
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more