A new solvent elimination interface based on the Monodisperse Aersol Generation Interface for Combining Liquid Chromatography with Fourier transform infrared (MAGIC-LC/FT-IR) spectrometry is described. The solvent elimination efficiency of MAGIC-LC/FT-IR was studied by varying the mobile-phase
composition from 100% methanol to 100% water. As the mobile-phase composition was varied, erythrosin B was injected into the interface and deposited on a KBr window after the solvent removal. Spectra were obtained which compared favorably with reference spectra, even as the mobile-phase water
content was increased. A reverse-phase separation was completed to demonstrate that readily identifiable spectra can be obtained from mobile phases containing high percentages of water, without heating of the effluent stream.
Department of Chemistry, School of Chemical Sciences, University of Georgia, Athens, Georgia 30602 2:
School of Chemistry, Georgia Institute of Technology, Atlanta, Georgia 30332
Publication date: November 1, 1988
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