A Study of Internal Standardization in Inductively Coupled Plasma-Mass Spectrometry

Authors: Thompson, Joseph J.; Houk, R. S.

Source: Applied Spectroscopy, Volume 41, Issue 5, Pages 715-921 (July 1987) , pp. 801-806(6)

Publisher: Society for Applied Spectroscopy

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Abstract:

Internal standardization is employed to compensate for ionization suppression in inductively coupled plasma-mass spectrometry (ICP-MS). By examination of the response of over 50 elements to a sodium matrix under different operating conditions, it is apparent that an internal standard is most effective when it is close in mass and ionization energy to the analyte. The extent of suppression and the relative order of suppression of various analyte elements can differ for various matrix elements. Generally, precision was improved by the use of internal standardization; the extent of improvement differed for different analyte elements and operating conditions. A comparison between ICP-MS with ultrasonic and pneumatic nebulization is described. The ultrasonic nebulizer usually exhibits better sensitivity and detection limits for analyte elements, unless the extent of suppression induced by the concomitant matrix is very high.

Keywords: Inductively coupled plasma-mass spectrometry (ICP-MS); Instrumentation, ICP-MS; Mass spectrometry

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702874448265

Affiliations: Ames Laboratory-U.S. Department of Energy and Department of Chemistry, Iowa State University, Ames, Iowa 50011; present address: Department of Chemistry, Ball State University, Muncie, IN 47306

Publication date: July 1, 1987

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