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Surface-Enhanced Raman Analysis of Benzo[A]Pyrene-DNA Adducts on Silver-Coated Cellulose Substrates

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Benzo[a]pyrene-7,8-diol-9,10 epoxide (BPDE)-DNA adducts have been analyzed by surface-enhanced Raman scattering (SERS) spectrometry. BPDE is the ultimate carcinogenic metabolite of benzo[a]pyrene. The SERS measurements were performed with the use of a silver-coated cellulose material as the SERS-active substrate. The acid hydrolyzed products of BPDE-DNA adducts, DNA, and the BP-tetrols were also analyzed by SERS. The results indicate that SERS has great promise as a tool for detecting BPDE-DNA adducts in biological samples.

Keywords: Analysis for DNA adducts benzo(a)pyrene; Analytical methods; Instrumentation, Raman spectroscopy; Raman spectroscopy; Surface-enhanced Raman; cw Lasers

Document Type: Research Article


Affiliations: Advanced Monitoring Development Group, Health and Safety Research Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831

Publication date: May 1, 1987

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