If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Infrared Spectroscopy of Aqueous Antibiotic Solutions

$29.00 plus tax (Refund Policy)

Buy Article:

Abstract:

Infrared spectra of aqueous antibiotic solutions were obtained using a new Liquid Analyzer accessory in a Fourier transform infrared (FT-IR) spectrometer. Based on a cylindrical internal reflectance element, the Liquid Analyzer accessory provides a sufficiently short (~0.015 mm) effective pathlength for infrared spectroscopy of aqueous solutions from 3200 to 800 cm−1. Spectra of aqueous solutions of penicillin VK, sodium oxacillin and sodium methicillin are shown. By measuring the absorbance of the beta-lactam carbonyl band, FT-IR spectroscopy with the accessory exhibits analytical sensitivity to less than 0.1% concentration by weight of antibiotic both in aqueous solution and in an actual fermentation broth.

Keywords: ATR spectroscopy; Fourier transform spectroscopy, infrared; Infrared spectra; Pharmaceuticals; Technique, spectroscopic

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702844554350

Affiliations: 1: IBM Instruments, Inc., Danbury, Connecticut 06810 2: General Analysis Corp., Darien, Connecticut 06820

Publication date: January 1, 1984

More about this publication?
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more