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A survey is given of developments leading to the application of laser-Raman spectroscopy in structural studies of viruses and model nucleoproteins. The major constituents of viruses-nucleic acid and protein molecules–exhibit Raman spectra which differ greatly from one another,
both in the spectral ranges that contain vibrational frequencies of conformational interest and in the relative intensities of Raman scattering of their respective subgroups. These features, not common to the infrared spectra, allow laser-Raman spectroscopy to be exploited for the study of
viral assembly and nucleoprotein interactions. Examples considered here are the RNA-containing virus MS2, the DNA-containing viruses Pfl and fd, and the complex of polylysine with DNA.
Department of Chemistry, Southeastern Massachusetts University, North Dartmouth, Massachusetts 02747
Publication date: September 1, 1976
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The Society publishes the internationally recognized, peer reviewed journal, Applied Spectroscopy, which is available both in print and online. Subscriptions are included with membership or can be purchased by institutional or corporate organizations. Abstracts may be viewed free of charge. Previously published as Bulletin (Society for Applied Spectroscopy)