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Optimum Conditions for Quantitative Measurements with the Nuclear Magnetic Resonance Spectrometer

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The application of nuclear magnetic resonance (NMR) spectroscopy to quantitative analysis is a relatively new and unexplored area, as evidenced by few reports in the literature on the subject. Jung-nickel and Forbes reported a study of the optimum operating conditions for measuring the integral signals representing the different protons of each of 26 compounds. These substances were studied as 30% solutions in carbon tetrachloride. Paulsen and Cooke made an extensive study of the theoretical considerations of measuring integral signals and the practical applications of these considerations. Methods have been published in which quantitative results are obtained through a comparison of peak heights or the use of an external standard. The study reported in this paper was designed to delineate the optimum-operating instrumental parameters and the limits of precision and accuracy that can be expected when integrating spectra with our present equipment. This equipment includes a Varian A-60 analytical NMR spectrometer and a Hewlett-Packard Model 405-BR digital voltmeter (which monitors the output of the dc amplifier of the integrator). The use of a digital voltmeter to measure integral signals has been described by Johnson and Schoolery and is given in the A-60 instruction manual.

Document Type: Short Communication


Affiliations: U. S. Department of Health, Education, and Welfare, Food and Drug Administration, Bureau of Science, Division of Pharmaceutical Chemistry, Washington, D. C. 20204

Publication date: May 1, 1967

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