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An Infrared Study of the Reaction of Barbiturates with p-Nitrobenzyl Chloride

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Abstract:

In alkaline media barbiturates of the general formula HNCONHCOCR'R"CO react with p-nitrobenzyl chloride to give derivatives of the composition NCONCOCH2 C6H2NO2CR'R"COCH2-C6H2NO2: It is postulated that the process of complex formation proceeds via the interaction of a negatively charged enolized barbituric acid ion with a positively charged p-nitrobenzyl ion. The infrared absorption spectra of the derivatives are in accord with this mechanism and suggest that in the complex the barbiturate is bonded to the p-nitrobenzyl money through the carbonyl oxygens in the 4 and 6 positions. The compounds show unique features throughout the region studied, 4000-650 cm−1, and hence the method affords a high degree of specificity for detecting and characterizing these sedative drugs.

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370257774633240

Affiliations: Food and Drug Laboratories, Department of National Health & Welfare, Ottawa, Canada

Publication date: November 1, 1957

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