Synthesis and In-vitro Evaluation of Platelet Aggregation Inhibitory Activity of Paeonol and its Analogues

Authors: Akamanchi K.G.1; Padmawar P.A.1; Thatte U.M.1; Rege N.N.2; Dahanukar S.A.2

Source: Pharmacy and Pharmacology Communications, Volume 5, Number 5, May 1999 , pp. 323-329(7)

Publisher: Pharmaceutical Press

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Abstract:

Paeonol (1-(2-hydroxy-4-methoxyphenyl)ethanone) and a series of substituted 1-(2-hydroxy-phenyl)ethanone derivatives were synthesized and screened as inhibitors of platelet aggregation.

The compounds with the greatest anti-platelet potential among the series tested were 1-(2,5-dihydroxyphenyl)ethanone (65·36% inhibition at 300 muM against 5 muM ADP), paeonol (36·31%), 1-(2-hydroxy-5-methoxyphenyl)ethanone (24·47%), 1-(2-hydroxy-5-nitrophenyl) ethanone (30·40%) and 1-(5-chloro-2-hydroxy-4-methylphenyl)ethanone (24·43%).

Language: English

Document Type: Research article

Affiliations: 1: Pharmaceutical Division, Department of Chemical Technology, University of Mumbai, Matunga-400 019, 2: Department of Pharmacology and Therapeutics, Seth G. S. Medical College, King Edward VII Memorial Hospital, Parel-400 012, Mumbai, India, kga@udct.ernet.in *

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