IngentaConnect Tracking genomic instability within irradiated and bystander popu...

Authors: Chapman, Kim L.¹; Kelly, James W.¹; Lee, Ryonfa²; Goodwin, Edwin H.³; Kadhim, Munira A.⁴

Source: Journal of Pharmacy and Pharmacology, Volume 60, Number 8, August 2008 , pp. 959-968(10)

Abstract:

Over the past two decades, our understanding of radiation biology has undergone a fundamental shift in paradigms away from deterministic 'hit-effect' relationships and towards complex ongoing 'cellular responses'. These responses include now familiar, but still poorly understood, phenomena associated with radiation exposure such as genomic instability and bystander effects. Although these responses share some common features (e.g. they occur at high frequency following very low doses, are heterogeneous in their induction and are observed at time points far removed from the initial radiation exposure), the precise relationship between genomic instability and bystander effects remains to be elucidated. This review will provide a synthesis of the known, and proposed, interrelationships among irradiated and bystander cellular responses to radiation. It also discusses our current experimental approach for gaining a clearer understanding of the relationship between damage induction and long-term effects in both irradiated and bystander cells.

Document Type: Research article

DOI: 10.1211/jpp.60.8.0003

Affiliations: 1: School of Life Sciences, Oxford Brookes University, Oxford, OX3 0BP, UK 2: Gesellschaft für Schwerionenforschung mbH (GSI), Planckstr. 1, 64291 Darmstadt, Germany 3: Bioscience Division, Los Alamos National Laboratory, MS M-888, Los Alamos, NM 87545, USA 4: School of Life Sciences, Oxford Brookes University, Oxford, OX3 0BP, UK., Email: m.kadhim@har.mrc.ac.uk

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Tracking genomic instability within irradiated and bystander populations