Turmeric-based diet can delay apoptosis without modulating NF-κB in unilateral ureteral obstruction in rats

Authors: Hashem, Reem M.¹; Soliman, Hala M.²; Shaapan, Sahar F.²

Source: Journal of Pharmacy and Pharmacology, Volume 60, Number 1, January 2008 , pp. 83-89(7)

Publisher: Pharmaceutical Press

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

The unilateral ureteral obstruction (UUO) model of renal injury in rat is characterized by nuclear factor κB (NF-κB) activation and tumour necrosis factor α (TNF-α) production, which induces apoptosis via activation of caspase 8 resulting in cell death. Curcumin, the major component found in turmeric spice, has been reported to provide protection against fibrosis and apoptosis elicited by UUO. This study examined the effects of a turmeric-based diet (5% w/w) on the apoptotic pathway induced by UUO in rats after 30 days of ligation. Administration of a turmeric-based diet demonstrated a significant decrease (P < 0.05) in mRNA expression of TNF-α and caspase 8, but not NF-κB, expression, which may contribute to the protective role of the turmeric-based diet. We conclude that a turmeric-based diet can delay apoptosis without modulating NF-κB, so as not to sensitize the mesangial cells to the apoptotic stimuli.

Document Type: Research article

DOI: 10.1211/jpp.60.1.0011

Affiliations: 1: Department of Biochemistry, Faculty of Pharmacy, Beni-suief University, Egypt 2: Department of Histology, Faculty of Medicine, Zagazig University, Egypt

Free content The full text is free.

View now: