Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting - a review

Authors: Zeitler, J. Axel1; Taday, Philip F.2; Newnham, David A.2; Pepper, Michael3; Gordon, Keith C.4; Rades, Thomas5

Source: Journal of Pharmacy and Pharmacology, Volume 59, Number 2, February 2007 , pp. 209-223(15)

Publisher: Pharmaceutical Press

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Abstract:

Terahertz pulsed spectroscopy (TPS) and terahertz pulsed imaging (TPI) are two novel techniques for the physical characterization of pharmaceutical drug materials and final solid dosage forms, utilizing spectral information in the far infrared region of the electromagnetic spectrum. This review focuses on the development and performance of pharmaceutical applications of terahertz technology compared with other tools for physical characterization. TPS can be used to characterize crystalline properties of drugs and excipients. Different polymorphic forms of a drug can be readily distinguished and quantified. Recent developments towards a better understanding of the fundamental theory behind spectroscopy in the far infrared have been discussed. Applications for TPI include the measurement of coating thickness and uniformity in coated pharmaceutical tablets, structural imaging and 3D chemical imaging of solid dosage forms.

Document Type: Research article

DOI: 10.1211/jpp.59.2.0008

Affiliations: 1: School of Pharmacy, University of Otago, P.O. Box 56, Dunedin, New Zealand; Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB3 0HE, UK; TeraView Limited, Platinum Building, St John's Innovation Park, Cambridge CB4 0WS, U 2: TeraView Limited, Platinum Building, St John's Innovation Park, Cambridge CB4 0WS, UK 3: Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB3 0HE, UK; TeraView Limited, Platinum Building, St John's Innovation Park, Cambridge CB4 0WS, UK 4: Department of Chemistry, University of Otago, P.O. Box 56, Dunedin, New Zealand 5: School of Pharmacy, University of Otago, P.O. Box 56, Dunedin, New Zealand

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