In-vitro and in-vivo antitumour activity of physalins B and D from Physalis angulata

Authors: Magalhães, Hemerson Iury Ferreira1; Veras, Maria Leopoldina2; Torres, Márcia Rocha1; Alves, Ana Paula Negreiros Nunes3; Pessoa, Otília Deusdênia Loiola2; Silveira, Edilberto Rocha2; Costa-Lotufo, Letícia Veras1; de Moraes, Manoel Odorico1; Pessoa, Cláudia1

Source: Journal of Pharmacy and Pharmacology, Volume 58, Number 2, February 2006 , pp. 235-241(7)

Publisher: Pharmaceutical Press

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

We have evaluated the in-vitro and in-vivo antitumour activity of physalin B and physalin D isolated from the aerial parts of Physalis angulata. In-vitro, both compounds displayed considerable cytotoxicity against several cancer cell lines, showing IC50 values in the range of 0.58 to 15.18 μg mL−1 for physalin B, and 0.28 to 2.43 μg mL−1 for physalin D. The antitumour activity of both compounds was confirmed in-vivo using mice bearing sarcoma 180 tumour cells. The in-vivo antitumour activity was related to the inhibition of tumour proliferation, as observed by the reduction of Ki67 staining in tumours of treated animals. Histopathological examination of the kidney and liver showed that both organs were affected by physalin treatment, but in a reversible manner. These compounds were probably responsible for the previously described antitumour activity of ethanol extracts of P. angulata, and their identification and characterization presented here could explain the ethnopharmacological use of this species in the treatment of cancer.

Document Type: Research article

DOI: 10.1211/jpp.58.2.0011

Affiliations: 1: Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, CP 3157, 60430-270, Brazil 2: Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, Fortaleza, Ceará, CP 12200, 60021-970, Brazil 3: Departamento de Clínica Odontológica da Faculdade de Odontologia, Farmácia e Enfermagem, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$38.34 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A