IngentaConnect Oral administration of a decaffeinated green tea (Camellia sinens...

Authors: Donovan, Jennifer L.¹; DeVane, C. Lindsay¹; Chavin, Kenneth D.²; Oates, James C.³; Njoku, Chinedu³; Patrick, Kennerly S.⁴; Fiorini, Ryan N.²; Markowitz, John S.⁴

Source: Journal of Pharmacy and Pharmacology, Volume 57, Number 10, October 2005 , pp. 1365-1369(5)

Publisher: Pharmaceutical Press

Abstract:

Oxidative stress is involved in the pathogenesis of numerous chronic human diseases. The objective of this study was to determine whether administration of a decaffeinated green tea extract providing 844 mg flavonoids daily reduced the urinary excretion of 8-epi-prostaglandin F₂ (8-epi-PGF₂), a product of lipid peroxidation in cellular membranes and of low-density lipoprotein (LDL). Nine healthy male and female subjects were studied at baseline and after 14 days of green tea supplementation. Analysis of urinary 8-epi-PGF₂ was performed using immunoaffinity extraction-gas chromatography-negative ion chemical ionization-mass spectrometry (GC-NICI-MS). Urinary 8-epi-PGF₂ concentrations were 0.286±0.120 nmol (mmol creatinine)^-1 at baseline and 0.244±0.177 nmol mmol^-1 creatinine after green tea supplementation. There were no significant differences in the excretion of urinary 8-epi-PGF₂ after treatment with green tea. We conclude that 14 days of green tea supplementation did not significantly alter in-vivo lipid peroxidation.

Document Type: Short communication

DOI: 10.1211/jpp.57.10.0017

Affiliations: 1: Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA 2: Department of Surgery, Division of Transplantation, Medical University of South Carolina, Charleston, South Carolina, USA 3: Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, South Carolina, USA 4: Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA

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Oral administration of a decaffeinated green tea (Camellia sinensis) extract did not alter urinary 8-epi-prostaglandin F2, a biomarker for in-vivo lipid peroxidation

Oral administration of a decaffeinated green tea (Camellia sinensis) extract did not alter urinary 8-epi-prostaglandin F₂, a biomarker for in-vivo lipid peroxidation