@article {Donovan:October 2005:0022-3573:1365, author = "Donovan, Jennifer L.", author = "DeVane, C. Lindsay", author = "Chavin, Kenneth D.", author = "Oates, James C.", author = "Njoku, Chinedu", author = "Patrick, Kennerly S.", author = "Fiorini, Ryan N.", author = "Markowitz, John S.", title = "Oral administration of a decaffeinated green tea (Camellia sinensis) extract did not alter urinary 8-epi-prostaglandin F2alpha, a biomarker for in-vivo lipid peroxidation", journal = "Journal of Pharmacy and Pharmacology", volume = "57", year = "October 2005", abstract = "Oxidative stress is involved in the pathogenesis of numerous chronic human diseases. The objective of this study was to determine whether administration of a decaffeinated green tea extract providing 844 mg flavonoids daily reduced the urinary excretion of 8-epi-prostaglandin F₂ (8-epi-PGF₂), a product of lipid peroxidation in cellular membranes and of low-density lipoprotein (LDL). Nine healthy male and female subjects were studied at baseline and after 14 days of green tea supplementation. Analysis of urinary 8-epi-PGF₂ was performed using immunoaffinity extraction-gas chromatography-negative ion chemical ionization-mass spectrometry (GC-NICI-MS). Urinary 8-epi-PGF₂ concentrations were 0.286±0.120 nmol (mmol creatinine)^-1 at baseline and 0.244±0.177 nmol mmol^-1 creatinine after green tea supplementation. There were no significant differences in the excretion of urinary 8-epi-PGF₂ after treatment with green tea. We conclude that 14 days of green tea supplementation did not significantly alter in-vivo lipid peroxidation.", pages = "1365-1369(5)", url = "http://www.ingentaconnect.com/content/rpsgb/jpp/2005/00000057/00000010/art00017" doi = "doi:10.1211/jpp.57.10.0017" }