@article {Maharaj:July 2005:0022-3573:877,
	author = "Maharaj, D.S.",
	author = "Maharaj, H.",
	author = "Antunes, E.M.",
	author = "Maree, D.M.",
	author = "Nyokong, T.",
	author = "Glass, B.D.",
	author = "Daya, S.",
	title = "6-Hydroxymelatonin protects against quinolinic-acid-induced oxidative neurotoxicity in the rat hippocampus",
	journal = "Journal of Pharmacy and Pharmacology",
	volume = "57",
	year = "July 2005",
	abstract = "Melatonin, a naturally occuring chemical mediator, although assigned a diverse range of functions, has attracted interest because of its ability to function as a free radical scavenger. Its major hepatic metabolite and photoproduct, 6-hydroxymelatonin (6-OHM), also shares this property. Since singlet oxygen and quinolinic acid (QUIN) are critically involved in the pathology of neurotoxicity, the objective of this study was to investigate the ability of 6-OHM to scavenge singlet oxygen and evaluate its ability to scavenge superoxide anions and reduce QUIN-induced neurotoxicity in the hippocampus in-vivo. The results show that 6-OHM is an efficient inhibitor of singlet oxygen formation as indicated by the rate constants and quantum yields reported for 6-OHM and zinc phthalocyanine (ZnPc), respectively. 6-OHM, appears to reduce QUIN-induced superoxide anion generation in the hippocampus, which provides some evidence of the neuroprotective effects of 6-OHM.",
	pages = "877-882(6)",
	url = "http://www.ingentaconnect.com/content/rpsgb/jpp/2005/00000057/00000007/art00010"
	doi = "doi:10.1211/0022357056424"
}