Histamine-3 receptor antagonists reduce superoxide anion generation and lipid peroxidation in rat brain homogenates
Authors: Badenhorst, H.E.1; Maharaj, D.S.2; Malan, S.F.1; Daya, S.2; van Dyk, S.1
Source: Journal of Pharmacy and Pharmacology, Volume 57, Number 6, June 2005 , pp. 781-786(6)
Publisher: Pharmaceutical Press
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Abstract:
Using a cyanide model to induce neurotoxic effects in rat brain homogenates, we examined the neuroprotective properties of three H3 antagonists, namely clobenpropit, thioperamide and impentamine, and compared them to aspirin, a known neuroprotective agent. Superoxide anion levels and malondialdehyde concentration were assessed using the nitroblue tetrazolium and lipid peroxidation assays. Clobenpropit and thioperamide significantly reduced superoxide anion generation and lipid peroxidation. Impentamine reduced lipid peroxidation at all concentrations used, but only reduced superoxide anion generation at a concentration of 1 mM. In the lipid peroxidation assay, all the drugs compared favourably to aspirin. This study demonstrates the potential of these agents to be neuroprotective by exerting antioxidant effects.Document Type: Short communication
DOI: 10.1211/0022357056064
Affiliations: 1: Pharmaceutical Chemistry, School of Pharmacy, North-West University, Potchefstroom 2520, South Africa 2: Division of Pharmacology, Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa
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