Development and evaluation of the essential oil from Magnolia fargesii for enhancing the transdermal absorption of theophylline and cianidanol
Authors: Jia-You Fang1; Tung-Hu Tsai2; Chi-Feng Hung3; Wen-Wen Wong1
Source: Journal of Pharmacy and Pharmacology, Volume 56, Number 12, December 2004 , pp. 1493-1500(8)
Publisher: Pharmaceutical Press
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Abstract:
To improve the skin permeation of theophylline and cianidanol ((+)-catechin), the essential oil of Magnolia fargesii was evaluated using in-vitro and in-vivo permeation techniques. Oxygenated monoterpenes and sesquiterpenes are the major components of M. fargesii essential oil. The in-vitro permeation of theophylline and cianidanol was significantly enhanced after treatment with M. fargesii essential oil. The essential oil increased the in-vivo skin deposition of cianidanol but not theophylline. On the other hand, in-vivo microdialysis showed a higher subcutaneous theophylline amount after essential oil treatment. In-vitro cell viability and prostaglandin E2 release by skin keratinocytes indicated that there was low or negligible cytotoxicity by M. fargesii essential oil. The in-vivo skin tolerance study determined by transepidermal water loss and colorimetry confirmed that no irritation of the skin was detected when using M. fargesii essential oil.Document Type: Research article
DOI: 10.1211/0022357044823
Affiliations: 1: Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan 2: National Research Institute of Chinese Medicine, Taipei, and Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan 3: School of Medicine, Fu Jen Catholic University, Taipei County, Taiwan
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