Astilbin prevents concanavalin A-induced liver injury by reducing TNF-
production and T lymphocyte adhesion
Authors: Wang J.1; Zhao Y.1; Xu Q.1
Source: Journal of Pharmacy and Pharmacology, Volume 56, Number 4, 1 April 2004 , pp. 495-502(8)
Publisher: Pharmaceutical Press
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Abstract:
The aim of this study was to evaluate the effect of astilbin on concanavalin A (Con A)-induced hepatitis, a T cell-dependent model of liver injury. Con A administration resulted in a severe liver injury in mice, with a strong increment in spleen cell adhesion and liver infiltration of T cells, as well as in tumour necrosis factor (TNF)- production. Against this liver injury, astilbin significantly inhibited the elevation in transaminase activity, reduced the TNF- production, and improved the histological changes, including inflammatory infiltration, hepatocyte necrosis and degeneration and Kupffer cell hyperplasia. In addition, astilbin inhibited the adhesion of spleen cells and purified T lymphocytes isolated from the liver-injured mice to fibronectin, laminin and type IV collagen. Moreover, the adhesion of human Jurkat T cells to endothelial cell line ECV-304 was also inhibited by astilbin. These results suggest that the improvement of the T cell-mediated liver injury by astilbin may be related to the reduction in TNF- production and in T cell adhesion to extracellular matrices and endothelial cells.
Document Type: Research article
DOI: 10.1211/0022357023033
Affiliations: 1: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Han Kou Road, Nanjing 210093, China
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