Induction of Apoptosis in Human Leukaemic Cell Lines K562, HL60 and U937 by Diethylhexylphthalate Isolated from Aloe vera Linne
Authors: Lee K.H.1; Hong H.S.2; Lee C.H.1; Kim C.H.1
Source: Journal of Pharmacy and Pharmacology, Volume 52, Number 8, 1 August 2000 , pp. 1037-1041(5)
Publisher: Pharmaceutical Press
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Abstract:
We investigated the effect of diethylhexylphthalate (DEHP) from Aloe vera Linne on the apoptosis of human leukaemic cell lines K562, HL60 and U937 to examine its pharmacological activity.At a level of 10
g mL-1 DEHP a significant anti-leukaemic effect was observed for all three cell lines, as measured by clonogenic assay. After treatment with 10 g mL-1 DEHP for 4 h, agarose gel electrophoresis and flow cytometric analysis confirmed the occurrence of apoptosis.These results indicate that DEHP isolated from Aloe vera Linne has a potent anti-leukaemic effect, and thus represents a new type of pharmacological activity with respect to human leukaemic cells.
Document Type: Research article
DOI: 10.1211/0022357001774778
Affiliations: 1: Animal Resource Research Center, Konkuk University, 93-1, Mojin-dong, Kwangjin-ku, Seoul, 143-701, Korea, chhan@kkucc.konkuk.ac.kr 2: Laboratory of Pharmacology, Ewha Women’s University Mokdong Hospital, 911-1 Mok-6-dong, Yangchon-ku, Seoul, 158-710, Korea
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