IngentaConnect Radish Extract Stimulates Motility of the Intestine via the Musca...

Authors: Jung K.Y.¹; Choo Y.K.¹; Kim H.M.¹; Choi B.K.²

Source: Journal of Pharmacy and Pharmacology, Volume 52, Number 8, 1 August 2000 , pp. 1031-1036(6)

Abstract:

effects of radish (Brassica oleraceae, Cruciferae) on gastrointestinal motility were examined using rat intestinal segments with myenteric plexus in-vitro and measuring the intestinal transit of charcoal in-vivo. Radish extract (10

g mL^-1 to 2 mg mL^-1) caused a dose-dependent increase in contractions of the duodenum, jejunum and ileum, and 1 mg mL^-1 was the maximum effective dose. The largest contraction by the extract was found in ileal segments. The extract-induced (0·5 mg mL^-1) ileal contraction was remarkably inhibited by pretreatment of segments with atropine (10^-7 M) for 10 min, but not by hexamethonium (0·5 mM). Moreover, antagonists of the muscarinic receptor reduced the radish-induced ileal contraction by a different ratio. The rank order of inhibitory effects was 4-diphenylacetoxy-N-methyl-(2-chloroethyl)-piperidine methiodide (90·5% of control)>tropicamide (67·4%)>pirenzepine (42·8%)>methoctramine (16·7%). Oral administration of radish extract (300–500 mg kg^-1 body weight) to mice remarkably improved the intestinal transit of charcoal, and this was significantly attenuated by co-administration of atropine (50 mg kg^-1). Taken together, these results suggest that radish extract stimulates gastrointestinal motility through activation of muscarinic pathways.

Document Type: Research article

DOI: 10.1211/0022357001774769

Affiliations: 1: Center of Oriental Medicinal Science, Chonbuk 570-749, Korea 2: Department of Pharmacology, School of Medicine, Chonbuk 570-749, Korea, wkuniv@wonkwang.ac.kr

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Radish Extract Stimulates Motility of the Intestine via the Muscarinic Receptors