The purpose of this article is to provide a critical review of the motivating factors, processes and outcomes pertaining to learning-centred curriculum reform in higher education. A case study example is provided from the Faculty of Pharmaceutical Sciences at the University of British Columbia. Although academic units on university campuses tend to present many unique contextual challenges, and are at different stages in curriculum re-design, useful lessons can be learned across settings without "re-inventing the wheel," or falling into similar implementation problems. A flexible framework, guiding principles and strategic approach to developing and implementing learning-centred curricula are provided to assist academic developers. Curricular reform has implications for learning communities, planning, assessment and programming in higher education.