Predicting emotional responses to potentially traumatic events from pre-exposure waking cortisol levels: a longitudinal study of police and firefighters
There is a large literature demonstrating that individuals who have experienced traumatic events have alterations in the hypothalamic-pituitary-adrenal (HPA) axis. However, the existing literature does not address the extent to which these alterations represent pre-existing risk factors
for developing psychopathology upon exposure to a significant stressor. In the current study, we examined the relationship between waking salivary cortisol level and physiological, personality, and psychological measures in 60 firefighters and police trainees during training, and then again
after exposure to a highly stressful, potentially traumatic event (PTE). Waking cortisol was negatively associated with neuroticism, but positively associated with physiological reactivity to loud tones and fear conditioning when assessed during training. Longitudinally, there were significant
negative correlations between pre-PTE waking cortisol and post-PTE negative mood and anxiety symptoms, but a positive correlation (trend) between pre-PTE waking cortisol and post-PTE physiological reactivity during recollection of the PTE. Thus, waking cortisol level may serve to predict divergent
types of emotional sequelae following PTEs.
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Document Type: Research Article
Women's Health Sciences Division, National Center for PTSD,VA Boston Healthcare System, Boston,MA, USA
Department of Psychiatry and Neurobiology,Mount Sinai School of Medicine, Bronx,NY, USA
Department of Psychiatry,Massachusetts General Hospital and Harvard Medical School, Boston,MA, USA
Research Service,Veterans Affairs Medical Center, Manchester,NH, USA
Publication date: 2013-05-01