IngentaConnect The effects of dietary cholesterol-lowering on psychological symp...

Authors: Weidner, Gerdi¹; Connor, Sonja²; Gerhard, Glenn²; Duell, P. Barton²; Connor, William²

Source: Psychology, Health and Medicine, Volume 14, Number 3, May 2009 , pp. 255-261(7)

Publisher: Routledge, part of the Taylor & Francis Group

Abstract:

The relationship of plasma cholesterol-reducing interventions to emotional states, such as depression and hostility, remains a topic of debate. The present study employed a randomised, controlled design, and was conducted at a clinical research center to test the effect of dietary cholesterol-lowering on psychological symptoms. Ten women and eight men were randomly assigned to one of two counterbalanced diet cycles (low-fat versus high-fat diet; isocaloric; 6 weeks each; separated by a washout period). Analyses for repeated measures revealed that the low-fat diet significantly reduced total, LDL and HDL cholesterol, when compared with baseline and the high-fat diet. As expected, weight remained unchanged. Ratings of depression, hostility and global severity of psychological symptoms as measured by the SCL-90-R also improved significantly on the low-fat, high-complex carbohydrate diet when compared with baseline. These results suggest that plasma cholesterol-lowering in the context of a low-fat, high-complex carbohydrate diet may have a beneficial effect on psychological symptoms.

Keywords: diet; cholesterol-lowering; hostility; depression

Document Type: Research article

DOI: 10.1080/13548500902730101

Affiliations: 1: San Francisco State University, San Francisco, California, USA 2: Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA

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The effects of dietary cholesterol-lowering on psychological symptoms: A randomised controlled study