This paper discusses the tenets of the politics of postmodern philosophy of science. At issue are Rouse's version of naturalism and his reading of Quine's distinction between the indeterminacy of translation and the underdetermination of theories by empirical evidence. I argue that the postmodern approach to science's research practices as patterns of interaction within the world is not in line with the naturalistic account Rouse aims at. I focus also on Rouse's readings of Heidegger's existential conception of science and Kuhn's concept of normal science. Finally, a strategy of defending science's cognitive distinctiveness in terms of hermeneutic philosophy is suggested as an alternative to the postmodern philosophy of science.