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What factors are associated with patient self-reported health status among HIV outpatients? A multi-centre UK study of biomedical and psychosocial factors

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Patient self-reported outcomes are increasingly important in measuring disease, treatment and care outcomes. It is unclear what constitutes well-being using a combined biomedical and psychosocial approach for patients with antiretroviral therapy (ART) access. This study aimed to determine the variance within the visual analogue scale (VAS) measure of health status using the existing five dimensions of the EuroQOL-5D, to identify which domains have the greatest effect on self-reported health status and to identify associations with the VAS using both biomedical and psychosocial factors among HIV outpatients. Consecutive patients in five UK clinics were recruited to a cross-sectional survey, n=778 (86% response rate). Patients self-completed validated measures, with treatment variables extracted from file. On the EuroQOL-5D, nearly one-third (28.1%) had mobility problems, one-fifth (18.7%) self-care problems, one-third (37.4%) difficulty in performing usual tasks and one-half (44.4%) reported pain/discomfort. In the regression model to determine associations with self-reported health status (VAS score), neither CD4 count nor ART status was associated with the outcome. However, in addition to four dimensions of the EuroQOL-5D, poorer health status was associated with worse physical symptom burden, treatment optimism and psychological symptoms. There is a relatively high prevalence of psychological morbidity and poor physical function, and these burdens of disease are associated with worse self-reported health status. As HIV management focuses on treatment for extended survival and a chronic model of disease, clinical attention to physical and psychological dimensions of patient care are essential to achieve optimal well-being.

Keywords: HIV; mental health; physical health; quality of life; self-report; symptoms

Document Type: Research Article


Affiliations: 1: King's College London, Department of Palliative Care, Policy and Rehabilitation,Cicely Saunders Institute, London, UK 2: Research Department of Infection and Population Health,Royal Free University College Medical School, London, UK 3: Brighton & Sussex University Hospitals NHS Trust, Brighton, UK 4: Royal Free Centre for HIV Medicine,Royal Free University College Medical School, London, UK 5: Department of Genitourinary Medicine,Mortimer Market Centre, Camden PCTLondon, UK 6: Homerton University Hospital NHS Foundation Trust, London, UK 7: Department of Primary Care and Population Sciences,Royal Free University College Medical School, London, UK

Publication date: 2012-08-01

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