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Quine's "Two Dogmas of Empiricism", a short paper which appeared 50 years ago in the Philosophical Review, was a milestone within the development of analytic philosophy. It was more important than many big volumes before and after. This might strike someone not familiar with the analytic tradition as a bit unusual; such impact one might expect from whole books like the Critique of Pure Reason or the Tractatus, but not from a 16 page paper. In these remarks, which opened a conference on Quine's seminal paper, I would like to indicate why "Two Dogmas" was and still is so important, not only as a standard topic of modern philosophical teaching and as a provocative treatment of the evergreen problem of analyticity, but also as one of the most challenging answers to the question what role philosophy can play in an age of science.