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New Fungicide Modes of Action Strengthen Disease Control Strategies

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Abstract:

Resistance, coupled with more stringent environmental and health requirements for registration, creates an urgency to discover and develop new fungicide modes of action. This paper reviews a number of new modes of action that already contribute to disease control strategies and highlights that damaging Oomycete pathogens are not fungi, so new modes of action either specifically control these pathogens, or they fail to combat them. New modes of action have shifted away from targets in biosynthetic pathways, toward core developmental processes involving the cytoskeleton, signal transduction and respiration. This has been accompanied by lower dose rates needed to achieve effective control. Cutting edge advances in many core developmental processes have resulted from better funded medical rather than agricultural research. Fungicide discovery programmes should quickly incorporate these advances in the search for wide-spectrum novel fungicides.

Keywords: CYTOSKELETON; FUNGICIDES; NEW MODES OF ACTION; RESISTANCE; RESPIRATION; SIGNAL TRANSDUCTION

Document Type: Research Article

DOI: http://dx.doi.org/10.1564/21jun02

Publication date: June 1, 2010

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