Fungicide resistance action committee (FRAC): a resistance activity update
Abstract:The activities of FRAC are managed by the Steering Committee and recently there have been several changes due to the retirement of members and the generation of a new Working Group. The newly formed Working Group is the Succinate Dehydrogenase Inhibitors (SDHI) Working Group. The FRAC Banana Working Group operates a system in which the Chairmanship rotates between companies. When new areas of chemistry are introduced to the market with two or more companies responsible for sales in the same market areas the work of FRAC expands to encompass this new chemistry by the formation of a new Working Group. The most recent example of this is the generation of the SDHI (Succinate Dehydrogenase Inhibitors) Working Group. The area of chemistry is not new and was previously known as 'carboximides' in FRAC Mode of Action Group C2. As the FRAC Code list is based on mode of action it was appropriate to name the Working Group and rename the chemical group to take this into account. The Code has not changed. The group includes such established molecules as carboxin, oxycarboxin, benodanil, flutolanil and mepronil, along with newer molecules e.g. boscalid, penthiopyrad, fenfuram showing a wider activity spectrum. The mode of action of the group is now well established: inhibition of Complex II, succinate dehydrogenase with all SDHIs binding in a similar way in the ubiquinone-binding site. Several mutations are known to be responsible for resistance and cross resistance studies have confirmed that all SDHIs are affected by them.
Document Type: Research Article
Publication date: 2009-06-01
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