Embryo aneuploidy screening for repeated implantation failure and unexplained recurrent miscarriage
Authors: Findikli, N.1; Kahraman, S.1; Saglam, Y.1; Beyazyurek, C.1; Sertyel, S.1; Karlikaya, G.1; Karagozoglu, H.1; Aygun, B.1
Source: Reproductive BioMedicine Online, Volume 13, Number 1, July 2006 , pp. 38-46(9)
Publisher: Reproductive Healthcare Ltd
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Abstract:
Among other factors, chromosomal abnormalities that originate from gametogenesis and preimplantation embryonic development are thought to be one of the major contributing factors for early embryonic death and failure of pregnancy. However, so far, no non-invasive technique exists that allows the detection of the chromosomal complement of an oocyte or a developing embryo as a whole. Rather, by removing polar bodies/blastomeres, recent developments on preimplantation genetic diagnosis for aneuploidy screening (PGD-AS) have paved the way to detect and possibly eliminate the majority of chromosomally abnormal embryos, thereby increasing the chance of a healthy pregnancy. This article summarizes the origin and impact of chromosomal abnormalities on human reproduction in cases with repeated implantation failure (RIF) and unexplained recurrent miscarriage. It also discusses recent advances regarding the possible benefits of PGD-AS in such cases.Keywords: ANEUPLOIDY SCREENING; CHROMOSOMAL ABNORMALITY; PGD; RECURRENT MISCARRIAGE; REPEATED IMPLANTATION FAILURE
Document Type: Research article
Affiliations: 1: Istanbul Memorial Hospital, ART, Reproductive Endocrinology and Genetics Unit, Piyalepasa Bulvari, 80270, Okmeydani, Istanbul, Turkey
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Click here for Page Help