Preimplantation genetic diagnosis for aneuploidy screening in repeated implantation failure

Authors: Caglar, Gamze Sinem¹; Asimakopoulos, Byron; Nikolettos, Nikos; Diedrich, Klaus; Al-Hasani, Safaa

Source: Reproductive BioMedicine Online, Volume 10, Number 3, March 2005 , pp. 381-389(9)

Publisher: Reproductive Healthcare Ltd

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Abstract:

Chromosomal abnormalities are thought to be responsible for implantation failure, and among chromosomal abnormalities in normally developing embryos, aneuploidy is the most frequent. Genetic testing of preimplantation embryos for chromosomal aneuploidy allows selection of chromosomally normal embryos, and early detection of chromosomal aberration will increase the chance of conceiving. Preimplantation genetic diagnosis for aneuploidy screening (PGD-AS), performed by polar body or blastomere analysis, is used in infertile patients treated with assisted reproduction technologies, especially in those with a poor prognosis, e.g. repeated IVF failure, advanced maternal age, or recurrent spontaneous abortion. The aim of this paper is to clarify the impact of PGD-AS in repeated implantation failure. In this review, the data collected so far regarding PGD-AS in this patient group will be discussed in depth.

Keywords: ANEUPLOIDY; PREIMPLANTATION GENETIC DIAGNOSIS; REPEATED IMPLANTATION FAILURE

Document Type: Research article

Affiliations: 1: Department of Obstetrics and Gynecology, Medical University, Lubeck, Germany

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