Heritability and candidate genes for endometriosis

Authors: Joe Leigh Simpson1; Farideh Bischoff2

Source: Reproductive BioMedicine Online, Volume 7, Number 2, September 2003 , pp. 162-169(8)

Publisher: Reproductive Healthcare Ltd

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Abstract:

Endometriosis is inherited in polygenic/multifactorial fashion, with recurrence risks of 5-7% for first-degree relatives. The current task is to determine the number and location of causative genes. This review initially supports the basis for polygenic/multifactorial inheritance and then outlines genome-wide strategies for identifying causative genes. Potential candidate genes are surveyed, and discrepant results emphasized. Finally, a hypothesis for endometriosis, having a multi-step pathogenesis analogous to the pathogenesis of neoplasia, is considered.

Keywords: candidate genes; endometriosis; heritability; multi-hit

Document Type: Review article

Affiliations: 1: Department of Obstetrics and Gynecology and Department of Molecular and Human Genetics, Baylor College of Medicine, 6550 Fannin, Suite 901A, Houston, TX 77030, USA 2: Department of Obstetrics and Gynecology, Baylor College of Medicine, 6550 Fannin, Suite 901A, Houston, TX 77030, USA

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