IngentaConnect New insights into maternal-fetal interactions at implantation

Authors: Gérard Chaouat¹; Sandrine Zourbas²; Sasa Ostojic³; Geneviève Lapprée-Delage⁴; Sylvie Dubanchet⁴; Natalie Ledée⁵; Jacques Martal⁴

Source: Reproductive BioMedicine Online, Volume 2, Number 3, May 2001 , pp. 198-203(6)

Publisher: Reproductive Healthcare Ltd

Abstract:

The immunotrophic theory was enunciated by Tom Wegmann. Since then, the involvement of cytokines in implantation and materno-fetal tolerance has emerged as a central topic in reproductive immunology. This brief survey covers the historical background leading to the specification of the crucial role of cytokines at the feto–maternal interface, and the present known patterns of their function. Focus is addressed to the most recent concept, e.g. pregnancy as a Th2 phenomenon (the immune response of the mother is biased towards the production of anti inflammatory cytokines, amongst them IL-10 which suppress inflammatory responses). A brief description of the role of inflammatory cytokines in implantation is presented to explain why it does not fit into such a scheme, and other recent data, for example on gamma

interferon, also fails to accord with the Th2 phenomenon.

Keywords: CYTOKINES; IMMUNOLOGY; IMPLANTATION; MATERNO-FETAL INTERACTIONS; PREGNANCY

Document Type: Research article

Affiliations: 1: U 131 INSERM, Equipe cytokines et relation materno foetale, Hôpital Antoine Béclère. 92141 Clamart, France 2: U 131 INSERM, Equipe cytokines et relation materno foetale, Hôpital Antoine Béclère. 92141Clamart, France; INRA,Endocrinologie de l'embryon. 78350 Jouy en Josas Cedex 3: U 131 INSERM, Equipe cytokines et relation materno foetale, Hôpital Antoine Béclère. 92141Clamart, France; University of Rijeka, Faculty of Medicine, Department of Biology, Brace Branchetta 22, 51000 Rijeka, Croatia 4: U 131 INSERM, Equipe cytokines et relation materno foetale, Hôpital Antoine Béclère. 92141Clamart, France 5: U 131 INSERM, Equipe cytokines et relation materno foetale, Hôpital Antoine Béclère. 92141Clamart, France; Service de Gynécologie Obstétrique, Hôpital Antoine Béclère. 92141. Clamart. France

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