Authors: Hynes, M.C.; Calder, P.; Rosenfeld, P.; Scott, G.

Source: Annals of The Royal College of Surgeons of England, Volume 87, Number 2, March 2005 , pp. 99-101(3)

Publisher: The Royal College of Surgeons of England

Abstract:

Introduction: To test the hypothesis that the fall in haemoglobin following total hip arthroplasty is reduced by tranexamic acid administration.

Patients and Methods: A cohort of 64 patients were studied, 32 received tranexamic acid 20 mg/kg on induction. Surgery was performed by the senior author in a standardised fashion. Haemoglobin levels were measured 2 weeks pre- and 3 days postoperatively. Any complications were noted. The study group was matched using the bone and joint research database for age, sex, procedure, disease and pre-operative haemoglobin level.

Results: In the group receiving no tranexamic acid, the mean fall in haemoglobin was 3.8 g/dl (CI of mean 3.4-4.3) and in the group treated with tranexamic acid 2.8 g/dl (CI of mean 2.5-3.2) P < 0.05. Complications included one non-fatal pulmonary embolus in the tranexamic acid group.

Conclusions: The administration of 20 mg/kg of tranexamic acid on induction of surgery is an effective method of reducing the haemoglobin fall following hip arthroplasty.

References: 22 references open in new window

Articles that cite this article?

Keywords: TOTAL HIP ARTHROPLASTY; TRANEXAMIC ACID; BLOOD LOSS

Document Type: Research article

DOI: http://dx.doi.org/10.1308/147870805X28118

Affiliations: 1: Bone and Joint Research Unit, The Royal London Hospital, Whitechapel, London, UK

Publication date: 2005-03-01

More about this publication?

• The Annals of The Royal College of Surgeons of England is the official journal of the College and is published eight times a year in January, March, April, May, July, September, October and November. The main aim of the journal is to publish high quality, peer-reviewed papers that relate to all branches of surgery.
  
  The Annals also includes letters and comments, a regular technical section, NICE news, controversial topics, CORESS feedback, book reviews and the best trainee presentations from England and Wales. The editorial board is composed of members of the College Council and experts from across the surgical specialties.
  
  Archive issues of the Annals of The Royal College of Surgeons of England are available via the PubMed Central database
  
  To view articles that have been published online ahead of print please click here
• Information for Authors
• Subscribe to this Title
• Information for Advertisers
• The journals of importance to UK clinicians - Survey
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Medicine ,  Surgery ,  Education
• By this author: Hynes, M.C. ;  Calder, P. ;  Rosenfeld, P. ;  Scott, G.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers