Authors: Jenkins, Peter O.; Turner, Martin R.; Jenkins, Paul F.

Source: Clinical Medicine, Journal of the Royal College of Physicians, Volume 8, Number 3, June 2008 , pp. 253-258(6)

Publisher: Royal College of Physicians

Abstract:

The global burden of stroke, the undisputed success of intravenous thrombolysis in the management of myocardial infarction and subsequent evidence from animal models of cerebral infarction have all fuelled intense interest in the potential role for thrombolytic agents in the acute management of stroke in clinical practice. Before any clinical treatment is introduced universally its safety and efficacy must be demonstrated in the routine clinical environment and not just within the ideal conditions of controlled clinical trials. Similarly, the cost effectiveness of a new treatment modality is an essential consideration before its use is promulgated. This paper reviews the current scientific evidence for thrombolysis in stroke with reference to issues of safety, efficacy and cost effectiveness.

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Keywords: CEREBRAL HAEMORRHAGE; CEREBRAL INFARCTION; COST EFFECTIVENESS; STROKE; THROMBOLYSIS; TISSUE PLASMINOGEN ACTIVATOR

Document Type: Research article

Publication date: 2008-06-01

More about this publication?

• Clinical Medicine is published six times a year and circulated to 20,000 Fellows and Members of the Royal College of Physicians. The journal is read by physicians both established and in training in hospitals across the world. It features a wide range of articles including original papers, professional issues, clinical guidance, medical humanities, ethics and clinical governance. The journal publishes the key features from the College lectures and conferences. Each issue has a CME section which reviews the latest advances in a chosen specialty.
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