Authors: Lucas, S.B.; Curtis, H.; Johnson, M.A.

Source: Clinical Medicine, Journal of the Royal College of Physicians, Volume 8, Number 3, June 2008 , pp. 250-252(3)

Publisher: Royal College of Physicians

Abstract:

This review describes patterns of mortality among adults infected with HIV in the UK and assesses the contributions of late diagnosis of HIV infection and non-HIV-related disease to such mortality. In total, 387 adults with HIV who died between 1 October 2004 and 30 September 2005 after receiving care at 90 clinical centres in the UK were reviewed. Causes of death and scenarios accounting for death were measured. Of the 387 deaths, 218 (56.3%) were readily attributable to infection with HIV. Only 123 (31.8%) deaths were considered not directly related to HIV. Late diagnosis of HIV accounted for 24.0% of all deaths and 35.2% of HIV-related deaths. Infection with HIV remains the main cause of mortality among infected patients in the era of highly active antiretroviral therapy. Late diagnosis of infection with HIV may be the largest potentially remediable factor for HIV-associated death.

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Keywords: HIV DIAGNOSIS; HIV INFECTION; MORTALITY

Document Type: Research article

Publication date: 2008-06-01

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• Clinical Medicine is published six times a year and circulated to 20,000 Fellows and Members of the Royal College of Physicians. The journal is read by physicians both established and in training in hospitals across the world. It features a wide range of articles including original papers, professional issues, clinical guidance, medical humanities, ethics and clinical governance. The journal publishes the key features from the College lectures and conferences. Each issue has a CME section which reviews the latest advances in a chosen specialty.
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