Authors: Bloom, Steve; Wynne, Katie; Chaudhri, Owais

Source: Clinical Medicine, Journal of the Royal College of Physicians, Volume 5, Number 2, March 2005 , pp. 147-152(6)

Publisher: Royal College of Physicians

Abstract:

The worsening global epidemic of obesity has increased the urgency of research aimed at understanding the mechanisms of appetite regulation. An important aspect of the complex pathways involved in modulating energy intake is the interaction between hormonal signals of energy status released from the gut in response to a meal, and appetite centres in the brain and brainstem. In particular, the gut peptides cholecystokinin, peptide YY, glucagonlike peptide 1, oxyntomodulin and pancreatic polypeptide have been implicated in signaling satiety post-prandially. The ultimate goal of work in this field is the development of effective treatments for obesity, and manipulation of these gut-brain axes offers potentially useful strategies for the conquest of this significant cause of morbidity and mortality and future burden on healthcare systems worldwide.

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Keywords: APPETITE; CHOLECYSTOKININ; GHRELIN; GLUCAGON-LIKE PEPTIDE 1; GUT PEPTIDES; HYPOTHALAMUS; OXYNTOMODULIN; PANCREATIC POLYPEPTIDE; PEPTIDE YY

Document Type: Short communication

Publication date: 2005-03-01

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• Clinical Medicine is published six times a year and circulated to 20,000 Fellows and Members of the Royal College of Physicians. The journal is read by physicians both established and in training in hospitals across the world. It features a wide range of articles including original papers, professional issues, clinical guidance, medical humanities, ethics and clinical governance. The journal publishes the key features from the College lectures and conferences. Each issue has a CME section which reviews the latest advances in a chosen specialty.
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