Authors: Menezo, Victor; Lightman, Susan

Source: Clinical Medicine, Journal of the Royal College of Physicians, Volume 4, Number 3, 1 May 2004 , pp. 250-254(5)

Publisher: Royal College of Physicians

Abstract:

The term 'vasculitis' includes a wide range of disorders characterised by inflammation of the wall of blood vessels, sometimes with necrosis, leading to ischaemia of the affected organ. The exact pathogenesis of most of these vasculitides is not fully understood and although the presence of circulating auto-antibodies seems to be a common feature among them, each vasculitis has its unique pathogenesis and a predilection for vessels of a defined size. Systemic vasculitis may be associated with ocular complications which include scleritis, keratitis, uveitis and optic neuropathy. These can precede the symptoms/signs of the systemic disease and therefore their recognition may lead to detection of the underlying disorder. The eye may also be affected by the treatment required to control the systemic disease.

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Keywords: CORTICOSTEROIDS; CYCLOSPORIN; ISCHAEMIA; KERATITIS; MYCOPHENOLATE MOFETIL; RETINITIS; SCLERITIS; UVEITIS

Document Type: Review article

Publication date: 2004-05-01

More about this publication?

• Clinical Medicine is published six times a year and circulated to 20,000 Fellows and Members of the Royal College of Physicians. The journal is read by physicians both established and in training in hospitals across the world. It features a wide range of articles including original papers, professional issues, clinical guidance, medical humanities, ethics and clinical governance. The journal publishes the key features from the College lectures and conferences. Each issue has a CME section which reviews the latest advances in a chosen specialty.
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