Author: Grasby, P.M.

Source: Clinical Medicine, Journal of the Royal College of Physicians, Volume 2, Number 1, 1 January 2002 , pp. 67-73(7)

Publisher: Royal College of Physicians

Abstract:

Neurochemical transmission is a fundamental element of brain organisation that has been relatively unexplored in the living human brain. Continuing advances in radionuclide imaging, particularly positron emission tomography (PET) and single photon emission tomography (SPET), mean that elements of neurochemical transmission can now be directly measured in vivo. With these techniques convincing abnormalities of monoaminergic neurotransmitter systems have been revealed in illnesses such as Parkinson's disease and schizophrenia. Furthermore, mechanisms of drug action and treatment responses can be monitored in vivo. This brief review describes some of our recent attempts to image the neurochemical brain in health and disease at the MRC Cyclotron Unit, Hammersmith Hospital, London.

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Keywords: NEUROCHEMISTRY; BRAIN; IMAGING; DEPRESSION; SCHIZOPHRENIA; PARKINSON'S; DISEASE; DOPAMINE; SEROTONIN

Document Type: Research article

Publication date: 2002-01-01

More about this publication?

• Clinical Medicine is published six times a year and circulated to 20,000 Fellows and Members of the Royal College of Physicians. The journal is read by physicians both established and in training in hospitals across the world. It features a wide range of articles including original papers, professional issues, clinical guidance, medical humanities, ethics and clinical governance. The journal publishes the key features from the College lectures and conferences. Each issue has a CME section which reviews the latest advances in a chosen specialty.
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