IngentaConnect Withdrawal from long-term benzodiazepine use: randomised trial in...

Abstract:

Background:

The long-term use of benzodiazepines is highly prevalent in developed societies and is not devoid of risks. Withdrawing patients from these drugs is often difficult. Tapering off benzodiazepines has been shown to be a good strategy for discontinuing their long-term use.

Aim:

To establish the efficacy of an intervention programme for reducing the chronic use of benzodiazepines.

Design of study:

Randomised, two-arm, parallel, non-blinded controlled trial.

Setting:

Three urban healthcare centres covering a population of 50 000 inhabitants (Mallorca, Spain).

Method:

Adult patients (n = 139) taking benzodiazepines daily for more than a year and visited by their family physician were randomised into an intervention group (n = 73) that received standardised advice and a tapering off schedule with biweekly follow-up visits, or into a control group (n = 66), that was managed following routine clinical practice. Both were followed for a year.

Results:

Patients achieved withdrawal or reduced their dose by at least 50% after 6 and 12 months. Abstinence and withdrawal symptoms were also measured. Both groups were homogeneous for personal, clinical and psychological characteristics and for benzodiazepine use. Only two patients from each group were lost to follow-up. After 12 months, 33 (45.2%) patients in the intervention group and six (9.1%) in the control group had discontinued benzodiazepine use; relative risk = 4.97 (95% confidence interval [CI] = 2.2 to 11.1), absolute risk reduction = 0.36 (95% CI = 0.22 to 0.50). For every three interventions, one patient achieved withdrawal. Sixteen (21.9%) subjects from the intervention group and 11 (16.7%) controls reduced their initial dose by more than 50%.

Conclusion:

Standardised advice given by the family physician, together with a tapering off schedule, is effective for withdrawing patients from long-term benzodiazepine use and is feasible in primary care.

Keywords: BENZODIAZEPINES; PRIMARY HEALTH CARE; RANDOMISED TRIAL; WITHDRAWAL SYMPTOMS

Document Type: Research article

Affiliations: 1: Centre de Salut Son Serra-la Vileta, Family and Community Medicine Teaching Unit. Palma de Mallorca, Mallorca, Spain 2: Research Unit, Geréncia d'Atenció Primária de Mallorca, University Institute of Health Sciences Research (IUNICS), Mallorca, Spain 3: Hospital Universitario Son Dureta, Servei de Salut de les Illes Balears, Mallorca, Spain 4: Centre de Salut Son Gotleu, Family and Community Medicine Teaching Unit, Spain 5: Centre do Salut Manacor, Family and Community Medicine Teaching Unit, Spain

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Withdrawal from long-term benzodiazepine use: randomised trial in family practice