Cerebrospinal fluid TAU protein and amyloid 42 in mild cognitive impairment: prediction of progression to Alzheimer's disease and correlation with the neuropsychological examination

Authors: Ivanoiu, Adrian¹; Jm Sindic, Christian¹

Source: Neurocase, Volume 11, Number 1, February 2005 , pp. 32-39(8)

Publisher: Psychology Press, part of the Taylor & Francis Group

Abstract:

Cerebrospinal fluid (CSF) TAU protein and Amyloid ß42 were able to distinguish between 28 mild cognitive impairment (MCI) patients and both 38 normal aged and 17 anxious and depressed elderly patients, with good sensitivity/specificity when the two measures were combined. These biological markers are independent predictors of the presence of Alzheimer disease (AD), in addition to memory performance. Low Amyloid ß42 level was predictor of a fast progression of MCI patients to full blown dementia. The TAU protein level tended to correlate with memory performance, presumably in relation with the extent of the bilateral medio-temporal damage in early AD.

Document Type: Research article

DOI: 10.1080/13554790490896901

Affiliations: 1: The Neurology Department, Memory Clinic and Neurochemistry Laboratory, Saint Luc University Hospital, Catholic University of Louvain, Brussels, Belgium

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