Knight's move thinking? Mild cognitive impairment in a chess player
Authors: Archer, H.A.1; Schott, J.M.1; Barnes, J.1; Fox, N.C.1; Holton, J.L.2; Revesz, T.2; Cipolotti, L.3; Rossor, M.N.1
Source: Neurocase, Volume 11, Number 1, February 2005 , pp. 26-31(6)
Publisher: Psychology Press, part of the Taylor & Francis Group
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Abstract:
We report the case of a chess player with superior premorbid cognitive function who presented to the Cognitive Disorders clinic at the National Hospital for Neurology and Neurosurgery with a 2-year history of symptoms of possible memory loss. Initially the MRI scan appearance was within normal limits and his cognitive scores inside the normal range; subsequently his cognitive function deteriorated and he fulfilled criteria for Mild Cognitive Impairment (MCI) two years later. Unexpectedly he died of an unrelated illness seven months later and post mortem examination of the brain was carried out, revealing advanced Alzheimer's disease (CERAD definite and NIA-Regan Institute high likelihood). This case highlights the difficulties encountered in assessing patients with superior premorbid function in the early stages of Alzheimer's disease, and reveals the value of serial MRI and neuropsychological assessment in detecting and monitoring early neurodegenerative disease.Document Type: Research article
DOI: 10.1080/13554790490896875
Affiliations: 1: The Dementia Research Centre, The National Hospital for Neurology and Neurosurgery, London, UK 2: Queen Square Brain Bank, Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK 3: Department of Neuropsychology, The National Hospital for Neurology and Neurosurgery, London, UK
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