Authors: Barr, John R.¹; Pierce, Carrie L.¹; Smith, J. Richard²; Capacio, Benedict R.²; Woolfitt, Adrian R.¹; Solano, Maria I.¹; Wooten, Joe V.¹; Lemire, Sharon W.¹; Thomas, Jerry D.¹; Ash, Doris H.¹; Ashley, David L.¹

Source: Journal of Analytical Toxicology, Volume 32, Number 1, January/February 2008 , pp. 10-16(7)

Publisher: Preston Publications

Abstract:

In July 2004, two individuals developed blisters after the destruction of a WWI-era munition. To determine the causative agent, urine samples were collected from both the highly blistered patient (patient 1; 6.5% of total body surface area) and patient 2, who had only one small blister. Their urine was analyzed for metabolites of known vesicants including sulfur mustard (HD), Lewisite (L1), and nitrogen mustards. The urine samples only tested positive for metabolites of HD. Additional metabolites were measured to confirm the exposure of sulfur mustard agent HD, including thiodiglycol (TDG), TDG-sulfoxide, and the bis-mercapturate of mustard sulfone. On day 2 after the exposure, patient 1 had a β-lyase metabolite level of 41 ng/mL, and patient 2 had a level of 2.6 ng/mL. Detectable levels of the β-lyase metabolite were observed in patient 1 for 11 days and in patient 2 for 7 days. Levels of TDG and both TDG and its sulfoxide measured together in the urine of patient 1 were found to be 24 ng/mL and 50 ng/mL, respectively, on day 2. The bis-mercapturate of mustard sulfone was detected in patient 1 (3.1 ng/mL) on day 2 but was not detected in samples taken on subsequent days.

Document Type: Research article

Affiliations: 1: Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, Georgia 30341 2: U.S. Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, Maryland 21010-5400

Publication date: 2008-01-01

More about this publication?

• The Journal of Analytical Toxicology (JAT), established in 1977 and published 9 times a year, is the international source covering a broad range of clinical, forensic, and industrial laboratory topics regarding the isolation, identification, and quantitation of potentially toxic substances.

  With an emphasis on practical application, JAT articles provide improved and novel techniques for use in clinical, forensic, workplace, sports testing (doping), and other toxicology laboratories. Articles describe newly developed methods in immunoassay testing, gas chromatography, liquid chromatography, mass spectrometry, atomic absorption spectrometry, solid and liquid phase extraction techniques, and other analytical approaches. Worldwide readership includes toxicologists, pathologists, chemists, clinicians, researchers, and educators working in medical examiner and law enforcement laboratories, hospitals, university and independent analytical laboratories, as well as the drug manufacturing industry.

  Each year in October, we publish a special issue from the Society of Forensic Toxicologists.

  JAT, as determined by ISI Citation Index, is one of the two most referenced international journals in forensic science.

• Subscribe to this Title
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Ecology ,  Toxicology
• By this author: Barr, John R. ;  Pierce, Carrie L. ;  Smith, J. Richard ;  Capacio, Benedict R. ;  Woolfitt, Adrian R. ;  Solano, Maria I. ;  Wooten, Joe V. ;  Lemire, Sharon W. ;  Thomas, Jerry D. ;  Ash, Doris H. ;  Ashley, David L.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers