IngentaConnect Quantification of Dichloroiodomethane and Bromochloroiodomethane ...

Authors: Silva, Lalith K.¹; Bonin, Michael A.¹; McKague, Bruce²; Blount, Benjamin C.¹

Source: Journal of Analytical Toxicology, Volume 30, Number 9, November/December 2006 , pp. 670-678(9)

Abstract:

Iodine-containing trihalomethanes (iodo-THMs) are formed as disinfection byproducts when iodide-containing water is disinfected using chloramination process. Subsequent water use may lead to human exposure to iodo-THMs. Because of health concerns surrounding exposure to iodo-THMs, a rapid, reliable, and high-throughput analytical method was developed to quantify trace levels of two iodo-THMs: dichloroiodomethane (IDCM) and bromochloroiodomethane (IBCM) in human blood. These analytes from the headspace above blood samples were extracted using solid-phase microextraction. Analytes were then desorbed and separated by capillary gas chromatography and analyzed by high-resolution mass spectrometry with multiple ion monitoring. This method utilizes stable isotope dilution to quantify parts-per-trillion levels of all analytes, with excellent precision of < 9% coefficient of variation. At three spiked levels, method accuracy of IDCM and IBCM ranged between 6 and 20% difference when comparing spiked and measured amounts. The method limit of detection was 2 ng/L for both IDCM and IBCM. This selective, sensitive, and rapid method will help to assess human exposure to iodo-THMs and to study potential associations between exposure and adverse health outcomes.

Document Type: Research article

Affiliations: 1: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 2: CanSyn Chemical Corporation, 200 College Street, Toronto, Ontario M5S 3E5, Canada

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Quantification of Dichloroiodomethane and Bromochloroiodomethane in Human Blood by Solid-Phase Microextraction Coupled with Gas Chromatography-High-Resolution Mass Spectrometry