Authors: Parker, Dawn R.; McIntyre, Iain M.

Source: Journal of Analytical Toxicology, Volume 29, Number 5, July/August 2005 , pp. 407-412(6)

Publisher: Preston Publications

Abstract:

The focus of this study was to determine if the analysis of a variety of postmortem biological specimens would aid in the toxicological interpretation of quetiapine in the cause and manner of death determinations. Postmortem quetiapine concentrations were examined in 21 medical examiner cases using liquid-liquid extraction and high-performance liquid chromatography analysis. Specimens analyzed were peripheral blood, central blood, liver, vitreous humor, and gastric contents, when available. Findings from this study suggest that therapeutic postmortem quetiapine concentrations may be less than 1 mg/L in both peripheral and central blood, less than 0.5 mg/L in vitreous, and less than 5 mg/kg in liver. Quetiapine concentrations indicative of toxicity were estimated at greater than 1 mg/L in peripheral and central blood, greater than 0.5 mg/L in vitreous, and greater than 5 mg/kg in the liver. Liver concentrations appeared to be particularly helpful in determining the potential for toxicity when compared with blood concentrations. Cases in which quetiapine was determined to play a significant role in the death indicated postmortem liver concentrations greater than 5 mg/kg. Cases in which quetiapine concentrations were considered incidental or noncontributory in the death had liver concentrations 2 mg/kg or less.

Document Type: Research article

Affiliations: 1: Forensic Toxicology Laboratory, San Diego County Medical Examiner's Office, 5555 Overland Avenue, Suite 1411, San Diego, California 92123-1270

Publication date: 2005-07-01

More about this publication?

• The Journal of Analytical Toxicology (JAT), established in 1977 and published 9 times a year, is the international source covering a broad range of clinical, forensic, and industrial laboratory topics regarding the isolation, identification, and quantitation of potentially toxic substances.

  With an emphasis on practical application, JAT articles provide improved and novel techniques for use in clinical, forensic, workplace, sports testing (doping), and other toxicology laboratories. Articles describe newly developed methods in immunoassay testing, gas chromatography, liquid chromatography, mass spectrometry, atomic absorption spectrometry, solid and liquid phase extraction techniques, and other analytical approaches. Worldwide readership includes toxicologists, pathologists, chemists, clinicians, researchers, and educators working in medical examiner and law enforcement laboratories, hospitals, university and independent analytical laboratories, as well as the drug manufacturing industry.

  Each year in October, we publish a special issue from the Society of Forensic Toxicologists.

  JAT, as determined by ISI Citation Index, is one of the two most referenced international journals in forensic science.

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