Authors: Charlier C.¹; Kintz P.²; Dubois N.¹; Plomteux G.¹

Source: Journal of Analytical Toxicology, Volume 28, Number 2, March 2004 , pp. 138-140(3)

Publisher: Preston Publications

Abstract:

This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart and peripheral blood concentrations of platinum were 1515 and 1253 µg/L, respectively. Concentrations in urine and bile were 1038 and 501 µg/L, respectively. Renal dialysis was started immediately after the end of cisplatin perfusion, when the mistake was noticed, but the patient deceased at day 16, presenting renal and hepatic insufficiency, ototoxicity, and pancytopenia.

Document Type: Research article

Affiliations: 1: Laboratory of Clinical Toxicology, University Hospital, Liege, Belgium 2: Institut de Médecine Légale, Faculté de Médecine de Strasbourg, 11 rue Humann, 67000 Strasbourg, France

Publication date: 2004-03-01

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  JAT, as determined by ISI Citation Index, is one of the two most referenced international journals in forensic science.

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