Free Content CASE REPORT: Fatal Overdosage with Cisplatin

Authors: Charlier C.1; Kintz P.2; Dubois N.1; Plomteux G.1

Source: Journal of Analytical Toxicology, Volume 28, Number 2, March 2004 , pp. 138-140(3)

Publisher: Preston Publications

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Abstract:

This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart and peripheral blood concentrations of platinum were 1515 and 1253 µg/L, respectively. Concentrations in urine and bile were 1038 and 501 µg/L, respectively. Renal dialysis was started immediately after the end of cisplatin perfusion, when the mistake was noticed, but the patient deceased at day 16, presenting renal and hepatic insufficiency, ototoxicity, and pancytopenia.

Document Type: Research article

Affiliations: 1: Laboratory of Clinical Toxicology, University Hospital, Liege, Belgium 2: Institut de Médecine Légale, Faculté de Médecine de Strasbourg, 11 rue Humann, 67000 Strasbourg, France

Publication date: 2004-03-01

More about this publication?
  • The Journal of Analytical Toxicology (JAT), established in 1977 and published 9 times a year, is the international source covering a broad range of clinical, forensic, and industrial laboratory topics regarding the isolation, identification, and quantitation of potentially toxic substances.

    With an emphasis on practical application, JAT articles provide improved and novel techniques for use in clinical, forensic, workplace, sports testing (doping), and other toxicology laboratories. Articles describe newly developed methods in immunoassay testing, gas chromatography, liquid chromatography, mass spectrometry, atomic absorption spectrometry, solid and liquid phase extraction techniques, and other analytical approaches. Worldwide readership includes toxicologists, pathologists, chemists, clinicians, researchers, and educators working in medical examiner and law enforcement laboratories, hospitals, university and independent analytical laboratories, as well as the drug manufacturing industry.

    Each year in October, we publish a special issue from the Society of Forensic Toxicologists.

    JAT, as determined by ISI Citation Index, is one of the two most referenced international journals in forensic science.

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