TECHNICAL NOTE: Application of ORAL-screen(TM) Saliva Drug Test for the Screening of Methamphetamine, MDMA, and MDEA Incorporated in Hair

Authors: Miki A.¹; Katagi M.¹; Shima N.¹; Tsuchihashi H.¹

Source: Journal of Analytical Toxicology, Volume 28, Number 2, March 2004 , pp. 132-134(3)

Publisher: Preston Publications

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Abstract:

By the use of a one-step immunoassay drug test for oral fluid, a convenient and fairly sensitive screening method has been devised for methamphetamine (MA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) incorporated in hair. These drugs, in a 10-mg portion of hair, were extracted into 5M HCl/methanol (1:20, v/v), and the extract reconstituted in 100 µL water was assayed with the saliva drug test ORAL·screen™. The limits of detection were 0.5 ng/mg hair for d-MA, 0.8 ng/mg for dl-MDMA, and 1.0 ng/mg for dl-MDEA. The results are in good agreement with those of gas chromatography–mass spectrometry (GC–MS) determination. Although all positive results must be confirmed by either GC–MS or a specific alternative methodology, this method provided a simple screening, suitable for drug enforcement purposes, while requiring only a 10-mg hair specimen.

Document Type: Research article

Affiliations: 1: Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ward, Osaka 541-0053, Japan

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