Authors: Dams R.¹; De Letter E.A.²; Mortier K.A.¹; Cordonnier J.A.³; Lambert W.E.¹; Piette M.H.A.²; Van Calenbergh S.⁴; De Leenheer A.P.¹

Source: Journal of Analytical Toxicology, Volume 27, Number 5, July/August 2003 , pp. 318-322(5)

Publisher: Preston Publications

Abstract:

We present a fatal case involving the combined ingestion of amphetamine, 3,4-methylenedioxymethylamphetamine, 3,4-methylenedioxyamphetamine, and paramethoxyamphetamine. Various postmortem specimens (e.g., several blood samples, urine, and tissue samples) were analyzed to study the distribution of the compounds and their metabolites in the human body. Quantitation took place using liquid chromatography-sonic spray ionization-mass spectrometry after pretreatment with a liquid-liquid extraction. The medico-legal findings were compatible with a disseminated intravascular coagulation induced by hyperthermia caused by the simultaneous intake of the amphetamine analogues.

Document Type: Research article

Affiliations: 1: Laboratorium voor Toxicologie, Universiteit Gent, Harelbekestraat 72, B-9000 Gent, Belgium 2: Vakgroep Gerechtelijke Geneeskunde, Universiteit Gent, Jozef Kluyskensstraat 29, B-9000 Gent, Belgium 3: Chemiphar NV, L. Bauwensstraat 4, B-8200 Brugge, Belgium 4: Laboratorium voor Medicinale Chemie, Universiteit Gent, Harelbekestraat 72, B-9000 Gent, Belgium

Publication date: 2003-07-01

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• The Journal of Analytical Toxicology (JAT), established in 1977 and published 9 times a year, is the international source covering a broad range of clinical, forensic, and industrial laboratory topics regarding the isolation, identification, and quantitation of potentially toxic substances.

  With an emphasis on practical application, JAT articles provide improved and novel techniques for use in clinical, forensic, workplace, sports testing (doping), and other toxicology laboratories. Articles describe newly developed methods in immunoassay testing, gas chromatography, liquid chromatography, mass spectrometry, atomic absorption spectrometry, solid and liquid phase extraction techniques, and other analytical approaches. Worldwide readership includes toxicologists, pathologists, chemists, clinicians, researchers, and educators working in medical examiner and law enforcement laboratories, hospitals, university and independent analytical laboratories, as well as the drug manufacturing industry.

  Each year in October, we publish a special issue from the Society of Forensic Toxicologists.

  JAT, as determined by ISI Citation Index, is one of the two most referenced international journals in forensic science.

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