Authors: Yen, C-C.¹; Liu, S-H.²; Chen, W-K.³; Lin, R-H.⁴; Lin-Shiau, S-Y.⁵

Source: Journal of Analytical Toxicology, Volume 26, Number 5, 1 July 2002 , pp. 286-296(11)

Publisher: Preston Publications

Abstract:

Mercury contents in biological samples can be measured by cold vapor atomic absorption spectroscopy combined with the flow-injection analysis system. However, water vapor in the absorption cell attenuated and distorted the signals. This study described the strategy to overcome this problem by adding an additional gas-liquid separator after the mixing/separator assembly. This modification can efficiently minimize the moisture in the transfer line and in the absorption cell. This improved technique was adopted to study the differential tissue distribution of methylmercury and HgS after oral administration to mice for five consecutive days. The present study suggests that the insoluble HgS (the main constituent of a Chinese mineral drug, cinnabar, used as a sedative) can still be absorbed from gastrointestinal tract and distributed to various tissues including the brain. As compared with methylmercury, the total amount of HgS accumulated in the tissues ranging about one five-thousandth of methylmercury, which is well correlated with the biological activity of HgS reported previously.

Document Type: Research article

Affiliations: 1: Institutes of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan and Departments of Biochemistry, College of Medicine, Chung Shan Medical University, Taichung, Taiwan 2: Institutes of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan 3: Departments of Biochemistry, College of Medicine, Chung Shan Medical University, Taichung, Taiwan 4: Departments of Pharmacology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan 5: Institutes of 1Toxicology and 2Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan

Publication date: 2002-07-01

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  With an emphasis on practical application, JAT articles provide improved and novel techniques for use in clinical, forensic, workplace, sports testing (doping), and other toxicology laboratories. Articles describe newly developed methods in immunoassay testing, gas chromatography, liquid chromatography, mass spectrometry, atomic absorption spectrometry, solid and liquid phase extraction techniques, and other analytical approaches. Worldwide readership includes toxicologists, pathologists, chemists, clinicians, researchers, and educators working in medical examiner and law enforcement laboratories, hospitals, university and independent analytical laboratories, as well as the drug manufacturing industry.

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