TECHNICAL NOTE: Identification and Quantitation of 11-Nor-9-Tetrahydrocannabivarin-9-Carboxylic Acid, a Major Metabolite of 9-Tetrahydrocannabivarin

Authors: ElSohly M.A.¹; Feng S.²; Murphy T.P.²; Warrington A.W.²; Ross S.³; Nimrod A.⁴; Mehmedic Z.⁴; Fortner N.⁵

Source: Journal of Analytical Toxicology, Volume 25, Number 6, September 2001 , pp. 476-480(5)

Publisher: Preston Publications

Abstract:

After incubation of ⁹-tetrahydrocannabivarin with human hepatocytes, a major metabolic product was detected by gas chromatography–mass spectrometry that showed identical retention time and mass spectrum to the synthetic 11-nor-⁹-tetrahydrocannabivarin-9-carboxylic acid (11-nor-⁹-THCV-9-COOH). Analysis of human urine specimens from marijuana users and plasma samples from Marinol® users showed that 11-nor-⁹-THCV-9-COOH was only present in urine specimens of marijuana users. These results supported the conclusion that identification of 11-nor-⁹-THCV-9-COOH in a donor's urine specimen indicates the use or ingestion of cannabis-related product(s) and would not explain the sole use of Marinol.

Language: English

Document Type:

Affiliations: 1: ElSohly Laboratories, Incorporated, 5 Industrial Park Drive, Oxford, Mississippi 38655; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677; Department of Pharmaceutics, School of Pharmacy, University of Mississippi, University, Mississippi 38677 2: ElSohly Laboratories, Incorporated, 5 Industrial Park Drive, Oxford, Mississippi 38655 3: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677; Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi 38677 4: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677 5: PharmChem Laboratories, 1505 O'Brien Drive, Menlo Park, California 94025

Publication date: 2001-09-01

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