TECHNICAL NOTE: Identification and Quantitation of 11-Nor-Delta9-Tetrahydrocannabivarin-9-Carboxylic Acid, a Major Metabolite of Delta9-Tetrahydrocannabivarin

Authors: ElSohly M.A.1; Feng S.2; Murphy T.P.2; Warrington A.W.2; Ross S.3; Nimrod A.4; Mehmedic Z.4; Fortner N.5

Source: Journal of Analytical Toxicology, Volume 25, Number 6, September 2001 , pp. 476-480(5)

Publisher: Preston Publications

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Abstract:

After incubation of Delta9-tetrahydrocannabivarin with human hepatocytes, a major metabolic product was detected by gas chromatography–mass spectrometry that showed identical retention time and mass spectrum to the synthetic 11-nor-Delta9-tetrahydrocannabivarin-9-carboxylic acid (11-nor-Delta9-THCV-9-COOH). Analysis of human urine specimens from marijuana users and plasma samples from Marinol® users showed that 11-nor-Delta9-THCV-9-COOH was only present in urine specimens of marijuana users. These results supported the conclusion that identification of 11-nor-Delta9-THCV-9-COOH in a donor's urine specimen indicates the use or ingestion of cannabis-related product(s) and would not explain the sole use of Marinol.

Language: English

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Affiliations: 1: ElSohly Laboratories, Incorporated, 5 Industrial Park Drive, Oxford, Mississippi 38655; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677; Department of Pharmaceutics, School of Pharmacy, University of Mississippi, University, Mississippi 38677 2: ElSohly Laboratories, Incorporated, 5 Industrial Park Drive, Oxford, Mississippi 38655 3: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677; Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi 38677 4: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677 5: PharmChem Laboratories, 1505 O'Brien Drive, Menlo Park, California 94025

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